Convert fluorescent biomarkers material on FJIRSM rare earth made ​​new progress in research

Compared with the traditional fluorescent marker molecule material ( such as a fluorescent dye ) , rare earth nano- conversion luminescent materials are not only high chemical stability, long fluorescence lifetimes , low potential toxicity, and because the excitation of near -infrared light having a larger optical penetration depth, no biological tissue autofluorescence of biological tissue and almost no damage and other significant advantages in biological fluorescence detection and imaging has important applications. Currently upconversion fluorescence labeling of nano materials development bottleneck problem is its low quantum yield . Conversion on improving luminous efficiency, explore new and efficient upconversion fluorescence labeling of nano materials has been the target of the focus of attention and effort , but also the availability of key materials such practical applications.

In the National Natural Science Fund for Distinguished Young and promote scientific and technological cooperation to support cross-strait joint fund , the Ministry of Science , " 863" , and major scientific instrument development projects , such as the Chinese Academy of strategic science and technology projects under the pilot , Fujian Institute of Research on the Structure of Chinese Academy of Sciences photoelectric materials Chemistry and Physics Laboratory research team and Chen yuan , State Key Laboratory of Structural Chemistry Huangming Dong research team , for the first time by thermal decomposition method , by injecting high-temperature coating precursor synthesized excellent luminescent properties of LiLuF4: Ln3 + core-shell structure on conversion nanocrystals . Multi-layer core-shell coating significantly improves the upconversion nanocrystals efficiency , which Er3 + and Tm3 + absolute quantum yield reached 5.0% and 7.6 % have been reported for the highest value of rare earth conversion monodisperse nanocrystals doped . Specifically , after the surface-modified nanocrystalline conversion as a fluorescent probe for high sensitivity detection of disease -specific markers . For example , the conversion of phase detection of β subunit of human chorionic gonadotropin (β-hCG, an important tumor marker ) detection limit of 3.8 ng / mL, with normal serum β-hCG in comparable level . In addition, the team through proof of concept experiments indicate LiLuF4 is a multifunctional nanoprobes biomarkers can be used for multi-modal biological imaging such as computed tomography (CT) imaging and targeted tumor cells convert fluorescent imaging . Recent research results related to the frontispiece (Frontispiece) published in the form of "German Applied Chemistry " magazine (Angew. Chem. Int. Ed. 2014, 53, 1252-1257), and was elected a hot papers.

Previously, Chen Yuan research team made ​​object detection of tumor markers in rare earth -based nano fluorescent probes related research progress (Coord. Chem Rev, 2014, DOI: 10.1016/j.ccr.2013.11.017; Chem Soc Rev.... in 2013 , 42, 6924 ) . For example the use of ultra-small CaF2: Ce3 + / Tb3 + nano fluorescent probes to achieve a human soluble urokinase receptor tumor markers (suPAR) time-resolved fluorescence resonance energy transfer (TR-FRET) detection (Angew. Chem Int Ed.. in 2013 , 52, 6671 ) .


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