Dioxopromethazine hydrochloride is also called grams of promethazine cough sensitivity and oxygen promethazine. The effect of relieving cough, asthma and ethanolamine draw hemp is stronger, which is equal to codeine. It’s used in the clinical antitussive, expectorant, acute or chronic bronchitis and cough caused by various diseases.

 

Light scattering phenomenon is so widespread in light and the particle in the process. It is refers when a beam of light passes the medium in the direction of the incident light in all directions outside, the phenomenon of a kind of optical radiation can be observed. Light scattering phenomenon is widespread in nature. Resonance light scattering technique using resonance light scattering probe mainly organic reagents, inorganic ion probe is less reported. In this paper, based on in phosphoric acid medium, the protonation of dioxopromethazine hydrochloride can form with polycondensation of tungsten acid radical ion association. The system resonance light scattering intensity is enhanced. And the intensity and the concentration of dioxopromethazine hydrochloride are within a certain scope to establish a new method for determination of dioxopromethazine hydrochloride. It’s used in testing dioxopromethazine hydrochloride in drgus.

 

The picture is absorption spectra of dioxopromethazine hydrochloride, sodium tungstate, dioxopromethazine hydrochloride and sodium tungstate system. Dioxopromethazine hydrochloride has two weak absorption bands in ultraviolet band, located at 225 nm and 264 nm, respectively. Sodium tungstate is colorless solution with weak absorption in the uv area. When adding trace of dioxopromethazine hydrochloride, absorbance of sodium tungstate solution increases. But the sensitivity is very low, which is unfavorable for the determination of dioxopromethazine.

 

Resonance light scattering spectra of dioxopromethazine hydrochloride and sodium tungstate interaction show that when dioxopromethazine and sodium tungstate coexist, resonance light scattering signal significantly enhances. And the scattering intensity within a certain range increases in ratio with the increase of the dioxopromethazine hydrochloride concentration. Under the optimum reaction conditions, dioxopromethazine hydrochloride and sodium tungstate react rapidly. After mixing all solution, the resonance light scattering intensity can reach the maximum and basic remain stable in 30 minutes. It can be used in the rapid determination of dioxopromethazine hydrochloride.